Ultrasound-Based Retina Prosthesis (U-RP)
The U-RP (Ultrasound-based Retina Prosthesis) is a noninvasive, dual-functional 2D ultrasound array engineered for simultaneous real-time imaging and programmable neurostimulation. Designed for retinal prosthesis applications, this 16×16 (256-channel), 4.5 MHz array enables image-guided ultrasound stimulation of retinal neurons without surgery, electrodes, or genetic modification. By integrating 3D imaging guidance with arbitrary 2D pattern generation, the U-RP dynamically projects complex visual patterns directly onto the retina — the first fully noninvasive ultrasound retina prosthesis with closed-loop auto-alignment.
Parameter | Specification |
|---|---|
Device Name | Ultrasound‑based Retina Prosthesis (U‑RP) |
Center Frequency | 4.5 MHz |
Array Configuration | 16×16 2D Matrix Array |
Number of Channels | 256 |
Piezoelectric Material | DL‑47 (PZT) |
Pitch Size | 0.75 mm |
Element Count | 256 |
Backing Layer | E‑Solder 3022 (5 mm) |
Matching Layer | Silver‑Epoxy Composite (λ/4) |
Protective Coating | Parylene‑C (10 μm) |
Imaging Mode | 3D B‑Mode Volume Reconstruction |
Stimulation Mode | Arbitrary 2D Pattern Generation |
Lateral Resolution | 81–590 μm (Frequency‑Dependent) |
Field of View | ≥6 mm × 6 mm (Full Rat Retina) |
Auto‑Alignment | Real‑Time 3D Imaging‑Guided (Depth + Tilt) |
Pattern Similarity | 0.91 ± 0.03 (Input vs. Neural Map) |
Acoustic Pressure (Threshold) | 1.7–5.8 MPa (Derated, Frequency‑Dependent) |
Thermal Index | <0.3 |
Temperature Rise | <0.5°C |
Safety Validation | OCT, ERG, Histology (2‑Week Chronic) |
Control System | Verasonics Vantage 256‑Channel |
Primary Application | Noninvasive Retinal Prosthesis |
Use Case | Retinitis Pigmentosa, AMD, Preclinical Vision Research |
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